Encapsulation Of β-Carotene And Curcumin In Liposome From Soybean Lecithin And L-α-Phosphatidylcholine Using SC-CO₂ With The Assistance Of Ultrasonication

Abstract The newest method to maintain better bioavailability of antioxidant compounds in the human digestive process is encapsulation using liposomes. liposomes used were lecithin from soybean seeds and L-α-Phosphatidylcholine. Furthermore, curcumin β-carotene encapsulated soy SC-CO2 with 100% ethanol, aquadest 50% v/v ethanol at 50°C, 60°C, 70°C pressure 15 MPa, 20 MPa 25 by ultrasonication for 60 minutes. This research was conducted obtain encapsulation, analyse effect on formation liposomes, operating conditions size determine characteristics analysed a UV-Vis Spectrophotometer Particle Size Analyzer (PSA) Dynamic Light Scattering also Scanning Electron Microscope (SEM) method. results PSA test showed that increase temperature resulted an liposome particle size. analysis proved content L-α-Phosphatidylcholine had results. It found SC-CO 2 +Sonicator higher concentrations condition temperature, content. use has increased stability suspensions prevented flocculation. SEM smallest distribution micro meters so it can be categorized as multilamellar vesicles (MLV).